How Do You Stop Meningiomas From Growing: A Comprehensive Guide to Management and Treatment
How Do You Stop Meningiomas From Growing: A Comprehensive Guide to Management and Treatment
The question of “how do you stop meningiomas from growing” is at the forefront for many individuals who have been diagnosed with these often slow-growing brain tumors. For some, it might be the nagging worry after an incidental finding, while for others, it’s a pressing concern as a known meningioma begins to show signs of change. I’ve spoken with countless individuals on their journey, and the shared sentiment is a desire for control, for understanding, and for proactive strategies to manage their health. It’s a deeply personal journey, and the path to managing meningiomas is rarely a one-size-fits-all approach.
Understanding Meningiomas: The First Step in Managing Growth
Before we delve into the methods of how to stop meningiomas from growing, it’s crucial to understand what these tumors are. Meningiomas are tumors that arise from the meninges, which are the protective membranes that surround the brain and spinal cord. They are typically benign, meaning they are not cancerous and do not spread to other parts of the body. However, their location within the skull or spinal canal can lead to symptoms as they grow and press on surrounding brain tissue or nerves.
The vast majority of meningiomas are considered Grade I (benign). However, there are also Grade II (atypical) and Grade III (malignant or anaplastic) meningiomas, which are rarer but can grow more aggressively and have a higher chance of recurrence. Understanding the specific grade and characteristics of a meningioma is paramount to determining the most effective strategy for managing its growth.
Key Characteristics of Meningiomas:
- Origin: Arise from the arachnoid mater, one of the meningeal layers.
- Prevalence: They are the most common primary tumors of the central nervous system, accounting for about 30-35% of all primary brain tumors.
- Demographics: More common in women than men, and incidence increases with age, particularly after the age of 60.
- Growth Rate: Generally slow-growing; some may remain stable for years without causing problems.
- Symptoms: Symptoms depend on the tumor’s size and location, and can include headaches, seizures, vision or hearing problems, weakness in limbs, and personality changes.
The variability in meningioma behavior is truly remarkable. I’ve seen cases where a small meningioma found incidentally has remained unchanged for over a decade, requiring only periodic observation. Conversely, I’ve also encountered situations where a meningioma, even a benign one, has grown steadily, eventually necessitating intervention. This underscores why a personalized approach is so vital when considering how to stop meningiomas from growing.
The Crucial Role of Active Surveillance (Watchful Waiting)
For many diagnosed with a meningioma, especially small, asymptomatic ones, the initial and often ongoing strategy is active surveillance, often referred to as “watchful waiting.” This isn’t a passive approach; it’s a highly engaged process that involves regular medical follow-ups and imaging. The primary goal here isn’t to “stop” growth in the sense of preventing it entirely, but rather to monitor it very closely. If growth occurs, it’s detected early, allowing for timely intervention before significant symptoms or complications arise.
My perspective on active surveillance is that it’s a testament to modern medicine’s ability to manage conditions that don’t require immediate drastic action. It empowers patients to live their lives with less immediate disruption while ensuring their health is continuously assessed. It’s about being vigilant, not anxious.
Components of Active Surveillance:
- Regular Neurological Examinations: Your doctor will periodically assess your neurological function, checking for any new or worsening symptoms. This might include evaluating your vision, hearing, strength, sensation, and coordination.
- Serial Imaging: This is perhaps the most critical component. Magnetic Resonance Imaging (MRI) is the gold standard for monitoring meningiomas. Typically, these scans are performed at intervals determined by your neuro-oncologist or neurosurgeon. Initially, scans might be every six months to a year, and if the tumor remains stable, the intervals might be extended to every one to two years.
- Symptom Monitoring: Patients are encouraged to be attuned to any changes in their health and to report them promptly to their medical team. This includes new headaches, seizures, changes in vision or hearing, dizziness, or any new neurological deficits.
The decision to pursue active surveillance is made in collaboration with your medical team and is usually recommended for:
- Small meningiomas (typically under 2-3 cm).
- Asymptomatic meningiomas with no mass effect or significant surrounding edema (swelling).
- Patients who are not good surgical candidates due to age, other medical conditions, or personal preference.
- Certain tumor locations where intervention carries higher risks.
It’s important to remember that “watchful waiting” doesn’t mean abandoning the patient. It signifies a period of careful observation where the medical team is actively engaged, ready to pivot to other treatment modalities if growth or symptom development occurs. This approach acknowledges the slow-growing nature of many meningiomas and aims to minimize unnecessary interventions, which themselves can carry risks.
Surgical Intervention: The Primary Method for Removing Meningiomas
When a meningioma is growing, causing symptoms, or is of a size and location that poses a risk, surgical removal is often the primary and most definitive way to address it. The goal of surgery is to completely excise the tumor, thereby stopping its growth and alleviating pressure on the brain. The success of surgery depends on several factors, including the tumor’s size, location, adherence to surrounding structures, and the patient’s overall health.
From my experience, the prospect of brain surgery can be daunting. However, modern neurosurgical techniques, including microsurgery and intraoperative imaging, have significantly improved outcomes. The neurosurgeon’s expertise is paramount in determining the feasibility and extent of resection.
Types of Surgical Procedures:
- Craniotomy and Resection: This is the most common approach. A portion of the skull (bone flap) is removed to access the tumor. The surgeon then carefully dissects and removes as much of the tumor as possible. The bone flap is then replaced and secured.
- Endoscopic Endonasal Approach (EEA): For tumors located at the base of the skull, surgeons can sometimes access and remove them through the nostrils using an endoscope. This is a minimally invasive approach with potentially faster recovery times.
- Stereotactic Radiosurgery (SRS): While not traditional surgery, SRS is a highly precise radiation technique that delivers a high dose of radiation to the tumor in a single or few sessions. It’s often used for smaller meningiomas that are difficult to access surgically or for residual tumor after surgery. While it doesn’t remove the tumor, it aims to stop its growth by damaging the tumor cells’ DNA.
The decision for surgery is a complex one, weighing the benefits of tumor removal against the potential risks, which can include infection, bleeding, seizures, neurological deficits (such as weakness, speech difficulties, or vision changes), and cerebrospinal fluid (CSF) leak.
Factors Influencing Surgical Decisions:
- Tumor Size and Location: Larger tumors or those located near critical brain structures (like the brainstem, major blood vessels, or cranial nerves) may be more challenging to remove completely and carry higher risks.
- Tumor Grade: Higher-grade meningiomas may require more aggressive surgical resection, sometimes with adjuvant therapy, to prevent recurrence.
- Patient’s Age and Health: The patient’s overall health status and ability to tolerate surgery are critical considerations.
- Symptoms: Symptomatic meningiomas often warrant surgical intervention to relieve pressure and prevent further neurological damage.
Post-operative care is crucial. Patients are closely monitored in the hospital for signs of complications. Recovery time varies widely depending on the extent of the surgery and the individual patient, but it typically involves a period of rest and gradual return to normal activities. Regular follow-up imaging is essential even after successful surgical removal to detect any potential recurrence.
Radiation Therapy: A Powerful Tool for Controlling Meningioma Growth
When surgery isn’t a complete option, or for certain types of meningiomas, radiation therapy plays a significant role in stopping or slowing their growth. Radiation therapy uses high-energy rays to damage or destroy tumor cells. It’s a highly targeted treatment that can be very effective in controlling meningiomas, especially those that are difficult to resect completely or that recur.
I’ve observed that radiation therapy is often a source of anxiety for patients, as it conjures images of aggressive cancer treatments. However, modern radiation techniques are incredibly precise, minimizing damage to surrounding healthy brain tissue. It’s a testament to the advancements in medical technology that we can use radiation so effectively and safely for conditions like meningiomas.
Types of Radiation Therapy for Meningiomas:
- Stereotactic Radiosurgery (SRS): As mentioned earlier, SRS is a highly precise, single-session treatment that delivers a focused dose of radiation to the tumor. It’s ideal for smaller meningiomas and can be an alternative to surgery for some patients, or used for residual tumor after surgery.
- Fractionated Stereotactic Radiotherapy (FSRT): Similar to SRS, but the total radiation dose is divided into multiple smaller sessions (fractions) delivered over several weeks. This is often used for larger tumors or those located closer to sensitive structures, as it can reduce the risk of side effects.
- Intensity-Modulated Radiation Therapy (IMRT): This advanced technique allows for precise shaping of the radiation beam to match the tumor’s contours, delivering a higher dose to the tumor while sparing surrounding healthy tissues. It’s particularly useful for irregularly shaped tumors or those in complex locations.
Radiation therapy is typically delivered on an outpatient basis, meaning patients can go home after each session. The treatment course can last from one day (for SRS) to several weeks (for FSRT or IMRT).
When is Radiation Therapy Recommended?
- Incomplete Surgical Resection: If a surgeon cannot remove the entire meningioma, radiation may be used to treat any remaining tumor cells and prevent recurrence.
- Recurrent Meningiomas: If a meningioma grows back after surgery, radiation can be an effective option.
- High-Grade or Atypical Meningiomas: These types of meningiomas have a higher risk of recurrence and may benefit from adjuvant radiation therapy after surgery.
- Patients Unsuitable for Surgery: For individuals who are not candidates for surgery due to age, comorbidities, or tumor location, radiation therapy can be a primary treatment to control growth.
- Certain Skull Base Meningiomas: Some meningiomas in challenging locations at the skull base may be better managed with radiation therapy, either as a primary treatment or after partial resection.
Side effects from radiation therapy can vary but are generally related to the area treated. For brain tumors, potential side effects might include fatigue, hair loss (in the treatment field), temporary memory issues, or skin irritation. These are usually manageable and often resolve after treatment is completed. Long-term side effects are rare with modern techniques but are always discussed with the patient.
The Role of Medical Therapy and Targeted Treatments
While surgery and radiation remain the cornerstones of meningioma management, medical therapies are also being explored and, in some specific cases, utilized. For the vast majority of benign meningiomas, medical management is not a primary strategy to stop growth, but research is ongoing, particularly for aggressive or recurrent tumors.
Historically, there haven’t been many systemic drugs that have proven consistently effective for meningiomas. However, the understanding of the molecular pathways involved in meningioma development is growing, paving the way for more targeted therapies.
Current and Investigational Medical Therapies:
- Hormonal Therapies: Some meningiomas have hormone receptors (like progesterone receptors), leading to early research into hormonal therapies. However, the results have been mixed, and they are not standard treatment for most meningiomas.
- Tyrosine Kinase Inhibitors (TKIs): Drugs that target specific enzymes involved in cell growth are being investigated. For example, drugs targeting the PDGF receptor or its signaling pathway have shown some promise in early studies for aggressive meningiomas.
- Chemotherapy: Traditional chemotherapy is generally not very effective for meningiomas, especially the benign types. It is typically reserved for high-grade or recurrent anaplastic meningiomas where other options have been exhausted.
- Targeted Agents and Immunotherapy: Ongoing research is exploring novel agents that target specific genetic mutations or pathways found in meningiomas. Clinical trials are crucial for evaluating the safety and efficacy of these new treatments.
It’s essential to emphasize that the use of medical therapy for meningiomas is often in the context of clinical trials or for specific, rare, aggressive subtypes. If you are considering medical therapy, it’s crucial to discuss it thoroughly with your neuro-oncologist to understand the potential benefits, risks, and your eligibility for relevant trials.
My personal take on medical therapy is one of cautious optimism. While surgery and radiation are powerful tools, the prospect of effective systemic treatments offers hope, particularly for those with aggressive forms of the disease or for preventing recurrence. It’s a rapidly evolving field, and staying informed about new research is key.
Lifestyle Factors and Their Potential Impact
While there isn’t a definitive “cure” through lifestyle alone, and certainly no evidence that specific diets or supplements can stop a meningioma from growing, maintaining a healthy lifestyle is always beneficial for overall well-being and can support the body during treatment and recovery. It’s about empowering yourself with positive habits that can indirectly support your fight against the tumor or its treatment side effects.
I often encourage individuals to think about their lifestyle as building a strong foundation for their health. It’s not a direct attack on the tumor, but it certainly doesn’t hurt and can profoundly impact how one feels and copes.
Considerations for a Healthy Lifestyle:
- Balanced Diet: A diet rich in fruits, vegetables, whole grains, and lean proteins supports overall health and provides essential nutrients. While no specific “anti-meningioma” diet is proven, a nutrient-dense diet can bolster the immune system and energy levels.
- Regular Exercise: Moderate physical activity can improve mood, reduce stress, enhance circulation, and promote general well-being. It’s important to discuss any new exercise regimen with your doctor, especially after surgery or during radiation therapy.
- Stress Management: Chronic stress can negatively impact health. Techniques like mindfulness, meditation, yoga, or engaging in enjoyable hobbies can be beneficial for managing the emotional toll of a diagnosis.
- Adequate Sleep: Prioritizing good sleep hygiene is crucial for bodily repair and cognitive function, which can be particularly important for individuals dealing with brain-related conditions.
- Avoiding Smoking and Excessive Alcohol: These habits are detrimental to overall health and can potentially interfere with healing and treatment effectiveness.
It’s vital to approach any advice on lifestyle modifications with a critical eye and always consult your medical team before making significant changes. The focus should be on enhancing general health and well-being rather than expecting direct tumor control from these measures.
The Importance of a Multidisciplinary Medical Team
Managing a meningioma, especially when considering how to stop its growth, is a journey best undertaken with a dedicated multidisciplinary medical team. This team typically includes neurosurgeons, neuro-oncologists, radiation oncologists, neurologists, radiologists, neuropathologists, and sometimes specialized nurses and support staff.
The synergy between these specialists ensures that all aspects of the patient’s condition are considered, leading to a comprehensive and personalized treatment plan. It’s about bringing together diverse expertise to form the best possible strategy for each individual.
Key Roles in the Multidisciplinary Team:
- Neurosurgeon: Evaluates the tumor’s surgical resectability, performs surgery, and manages post-operative care.
- Neuro-oncologist: Specializes in brain tumors and their medical management, including chemotherapy, targeted therapies, and coordinating overall treatment.
- Radiation Oncologist: Designs and oversees radiation therapy treatment plans.
- Neurologist: Manages neurological symptoms, such as seizures, and monitors neurological function.
- Radiologist: Interprets MRI and CT scans, crucial for diagnosis and monitoring tumor growth.
- Pathologist: Analyzes tumor tissue to determine its type, grade, and specific characteristics, which guides treatment decisions.
Collaborating with such a team ensures that the patient receives the most up-to-date and evidence-based care. It’s about having a unified front against the meningioma, with each member contributing their specialized knowledge to the patient’s well-being. I cannot stress enough how vital this collaborative approach is for navigating the complexities of meningioma management.
Frequently Asked Questions About Stopping Meningioma Growth
Navigating the information about meningiomas can be overwhelming, and many common questions arise. Here, we address some of the most frequently asked questions to provide clarity and depth.
How quickly do meningiomas typically grow?
The growth rate of meningiomas can vary significantly, making it difficult to provide a single definitive answer. However, they are generally considered slow-growing tumors. Many benign (Grade I) meningiomas may grow only a few millimeters over several years, and some may not grow at all for extended periods. On average, estimates suggest that a meningioma might grow by about 1-2 mm per year, but this is a rough average and can be much faster or slower in individual cases.
Atypical (Grade II) and anaplastic (Grade III) meningiomas tend to grow more rapidly than benign ones. The rate of growth is influenced by factors such as the tumor’s specific genetic makeup, its location, and the patient’s individual biological response. For instance, a meningioma located in a confined space, like along a cranial nerve, might cause symptoms due to pressure even if its growth rate is modest, whereas a larger tumor in a less critical area might grow considerably before symptoms appear.
The key takeaway is that monitoring is essential. Regular imaging, such as MRI scans, allows physicians to track any changes in size and determine if the growth rate is accelerating or remaining stable. If a meningioma begins to grow rapidly or causes concerning symptoms, intervention becomes more likely. It’s also important to note that not all meningiomas grow; some remain stable indefinitely, especially small ones found incidentally.
Can I stop a meningioma from growing without surgery or radiation?
For most meningiomas, especially those that are actively growing or causing symptoms, surgery or radiation therapy are the primary established methods to stop or significantly slow their growth. There is currently no scientifically proven non-medical intervention, such as specific diets, supplements, or lifestyle changes alone, that can reliably stop a meningioma from growing.
However, this doesn’t mean lifestyle plays no role. Maintaining a healthy lifestyle, including a balanced diet, regular moderate exercise, adequate sleep, and stress management, can support your overall health and well-being. This can help your body better tolerate treatments like surgery or radiation and can aid in recovery. For small, asymptomatic meningiomas, active surveillance (watchful waiting) is a common approach. This involves regular monitoring with imaging and neurological exams, and intervention is only considered if the tumor shows significant growth or starts causing symptoms.
Research into medical therapies, such as targeted drugs and hormonal treatments, is ongoing, particularly for aggressive or recurrent meningiomas that do not respond well to surgery or radiation. These are typically part of clinical trials or reserved for specific situations and are not considered a primary strategy for stopping the growth of most typical meningiomas. Therefore, while lifestyle support is valuable, it should not be viewed as a substitute for medical interventions when they are deemed necessary by your healthcare team.
What are the risks associated with treating a growing meningioma?
The risks associated with treating a growing meningioma are dependent on the chosen treatment modality, the tumor’s specific characteristics (size, location, grade), and the patient’s overall health.
Surgical Risks:
* Infection: Any surgical procedure carries a risk of infection.
* Bleeding: Hemorrhage can occur during or after surgery.
* Cerebrospinal Fluid (CSF) Leak: The membranes surrounding the brain might leak fluid after surgery.
* Neurological Deficits: Depending on the tumor’s location and the extent of surgery, patients may experience new or worsened symptoms such as weakness, numbness, vision problems, hearing loss, speech difficulties, or balance issues. Damage to cranial nerves is a significant concern, especially for skull base meningiomas.
* Seizures: Surgery can sometimes trigger seizures.
* Anesthesia Risks: As with any surgery, there are risks associated with general anesthesia.
* Recurrence: Even after complete surgical removal, there is a small risk of the meningioma growing back, particularly for higher-grade tumors.
Radiation Therapy Risks:
* Fatigue: A common side effect of radiation.
* Hair Loss: Localized hair loss in the treatment area may occur.
* Skin Irritation: The skin in the treated area might become red or irritated.
* Cognitive Changes: In some cases, particularly with older radiation techniques or higher doses, there can be long-term cognitive effects, such as memory or concentration problems. Modern techniques like SRS and IMRT are designed to minimize these risks.
* Secondary Tumors: There is a very small, long-term risk of developing a new tumor in the irradiated area, though this is exceedingly rare with current precise techniques.
* Cranial Nerve Damage: If the radiation beam is near critical nerves, damage can occur, leading to symptoms like vision or hearing issues.
Medical Therapy Risks:
* The risks vary widely depending on the specific drug used. Side effects can range from mild gastrointestinal issues, fatigue, and skin rashes to more serious effects on blood counts, liver function, or heart function. These are carefully monitored by the medical team.
It is imperative that patients discuss these risks thoroughly with their neurosurgeon, radiation oncologist, or neuro-oncologist. They can provide personalized risk assessments based on individual factors and the specific treatment plan.
What is active surveillance, and is it a way to stop meningiomas from growing?
Active surveillance, often referred to as “watchful waiting,” is a management strategy for meningiomas where the tumor is closely monitored rather than immediately treated. It is not a method to *stop* the growth of a meningioma in the sense of preventing it from increasing in size. Instead, it’s a strategy to *manage* the tumor by detecting any growth or development of symptoms early.
The core components of active surveillance include:
* Regular MRI scans: To assess tumor size and appearance at prescribed intervals (e.g., every 6-12 months initially, then potentially spaced further apart if stable).
* Periodic neurological examinations: To check for any new or worsening symptoms.
* Patient self-monitoring: Encouraging patients to report any new health concerns to their medical team promptly.
Active surveillance is typically recommended for small, asymptomatic meningiomas, particularly those less than 2-3 cm in diameter, where the risks of immediate intervention (surgery or radiation) are considered to outweigh the benefits. It’s also an option for individuals who are not good surgical candidates due to other health issues or advanced age.
The goal of active surveillance is to avoid unnecessary treatments and their associated risks and side effects. If at any point the meningioma shows significant growth, begins to cause symptoms (like headaches, seizures, vision changes, etc.), or poses a future risk, then treatment such as surgery or radiation therapy is initiated. Therefore, active surveillance is a method of *monitoring* for growth and deciding *when* to intervene, rather than a method to actively prevent growth itself.
Are there any dietary recommendations that can help manage meningioma growth?
Currently, there is no specific diet scientifically proven to stop or slow the growth of meningiomas. While a healthy, balanced diet is crucial for overall well-being and can support the body during medical treatments, it is not a substitute for standard medical interventions like surgery or radiation therapy when they are indicated.
Some individuals explore dietary approaches based on anecdotal evidence or theories, but these lack robust scientific validation for meningioma treatment. It’s important to be cautious about claims suggesting that certain foods, supplements, or restrictive diets can cure or halt tumor growth.
What is generally recommended for individuals managing any serious health condition, including meningiomas, is a diet rich in:
* Fruits and vegetables: Providing essential vitamins, minerals, antioxidants, and fiber.
* Whole grains: For sustained energy and fiber.
* Lean proteins: Supporting tissue repair and immune function.
* Healthy fats: Found in sources like avocados, nuts, seeds, and olive oil.
Conversely, it’s often advised to limit processed foods, excessive sugar, and unhealthy fats. Staying well-hydrated is also important. However, it is essential to discuss any significant dietary changes or the use of supplements with your medical team, as some supplements can interfere with medications or treatments. For instance, some antioxidants might theoretically interfere with radiation therapy’s effectiveness, though this is still a subject of research. Always prioritize evidence-based medical care and consult your healthcare providers for personalized advice.
How do doctors determine if a meningioma needs to be treated versus monitored?
The decision of whether to treat a meningioma or monitor it closely is a multifaceted one, made by a multidisciplinary medical team in close consultation with the patient. Several key factors are considered:
1. Size of the Tumor: Very small meningiomas (often less than 2-3 cm in diameter) that are asymptomatic are typically candidates for active surveillance. Larger tumors are more likely to cause symptoms or press on critical structures, warranting treatment.
2. Location of the Tumor: Tumors located in critical areas of the brain or spinal cord, such as near the brainstem, optic nerves, or major blood vessels, are often treated even if they are small, due to the potential for significant neurological compromise. Conversely, a tumor in a less critical area might be monitored if it’s small and asymptomatic.
3. Symptoms: If a meningioma is causing symptoms – such as headaches, seizures, vision or hearing loss, weakness, or changes in personality – treatment is generally recommended to alleviate these symptoms and prevent further neurological damage.
4. **Tumor Grade and Agressiveness:** While most meningiomas are benign (Grade I), atypical (Grade II) and anaplastic (Grade III) meningiomas are more aggressive and have a higher risk of recurrence. These types are more likely to be treated aggressively, often with surgery followed by radiation or other therapies, even if they are currently small. Doctors use pathology reports from biopsies or surgically removed tumors to determine the grade.
5. Rate of Growth: If imaging shows that a meningioma is growing rapidly, intervention is usually necessary, even if it was previously stable. Doctors compare serial MRI scans to assess changes in tumor size over time.
6. Patient’s Age and Overall Health: The patient’s general health status, age, and ability to tolerate surgery or radiation are important considerations. For elderly patients or those with significant co-existing medical conditions, the risks of treatment might outweigh the benefits, leading to a preference for active surveillance if the tumor is not immediately threatening.
7. Patient Preference: Ultimately, the patient’s values and preferences play a crucial role in the decision-making process. Open communication with the medical team is essential to ensure the chosen path aligns with the patient’s goals and comfort level.
The decision is a dynamic one. A meningioma initially managed with active surveillance might require treatment later if any of these factors change.
Can meningiomas shrink or disappear on their own?
Meningiomas, by their nature as tumors formed by abnormal cell growth, do not typically shrink or disappear on their own without intervention. Unlike some benign conditions that might resolve spontaneously, meningiomas are structural growths.
While some very small, asymptomatic meningiomas might appear to show minimal change or even stabilize in size over long periods of observation, this is different from spontaneous regression. The consensus in neuro-oncology is that if a meningioma is present and detectable, it requires management or monitoring; it will not vanish without treatment.
The closest phenomenon to “shrinking” might be observed with certain advanced medical therapies in clinical trials, where a reduction in tumor size might occur, but this is a direct result of treatment and not a spontaneous event. For the vast majority of patients, a growing or symptomatic meningioma necessitates active medical intervention.
In conclusion, while the question of “how do you stop meningiomas from growing” is complex, it is met with a range of effective strategies. From vigilant active surveillance to precise surgical resection and advanced radiation techniques, medicine offers multiple pathways to manage these tumors. Understanding your specific situation, working closely with a multidisciplinary medical team, and staying informed are key to navigating this journey successfully. The goal is always to preserve quality of life while effectively controlling the tumor’s progression.